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Vitamin E (high-dose synthetic)

Also known as: dl-alpha-tocopherol, synthetic vitamin E

DDiscouraged1 studies referenced

Common dosage

Not recommended above 400 IU

Category

vitamin

Description

High-dose synthetic vitamin E (≥400 IU) has been associated with increased all-cause mortality and prostate cancer risk (SELECT trial). Low-dose mixed tocopherols from food are fine.

Safety & interactions

SELECT trial showed 17% increased prostate cancer risk. Meta-analyses link doses ≥400 IU to increased mortality.
Check all interactions →

Studies on Vitamin E (high-dose synthetic) (1)

1.

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Klein EA, et al. (2011) · JAMA · n=35,533

RCTPubMed

Health domains

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.